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Canada's approach to vaccinating people against swine flu is too slow to protect the most vulnerable, an editorial in Monday's Canadian Medical Association Journal says.
By CBC News
Monday, Aug. 31, 2009
Canada's approach to vaccinating people against swine flu is too slow to protect the most vulnerable, an editorial in Monday's Canadian Medical Association Journal says.
Health Canada has chosen to include an adjuvant — a substance used to stretch a vaccine's active ingredient and boost immune response to the serum — in the Canadian version of the vaccine against the H1N1 virus. Using an adjuvant requires a slower, more thorough licensing review process but ultimately allows more people to be immunized.
This approach is slower than providing the vaccine without adjuvant to high-risk groups to allow them to be immunized quickly, as the U.S., Europe and Australia are doing, Dr. Paul Hébert, editor-in-chief, and Dr. Noni MacDonald, senior editor of public health, said in their editorial.
"Time is running out," the doctors wrote. "Only by providing fast-track standard vaccine can high-risk groups be protected in a timely way, while the general public awaits the arrival of the adjuvant vaccine."
Protect high-risk Canadians
Complications such as severe acute lung injuries caused by the H1N1 pandemic strain have been mainly in adults, often First Nations people, those with chronic medical conditions and women late in pregnancy. Younger children have also been admitted to hospital at higher rates.
The earlier a vaccine is rolled for these high-risk individuals, the greater the chance to protect them before flu season peaks. It also reduces the burden on hospitals and scarce intensive care spaces, the editorial writers argued.
"Having enough vaccine for every Canadian would make more sense if the pandemic virus were highly virulent for large proportions of the population. But given current evidence, it seems a poorer choice than providing coverage to high-risk groups as early as possible."
Health Canada has chosen to treat this pandemic virus like a new subtype, which requires more extensive review and a slower rollout than if it were considered a variant strain of H1N1, the editorial writers said.
To protect the public, health professionals need access to standard vaccines by early October and vaccine with adjuvant no later than mid-November, they suggested.
The pair stressed they are not suggesting sacrificing safety, but highlighting the need to adjust plans quickly depending on the results of safety and effectiveness trials that will start to be completed soon.
Using an adjuvant might make sense if results suggest that the vaccine is not effective without it, but if results show a good performance from fast-tracked vaccine without the adjuvant, Canada currently has no way to license such a vaccine quickly, the editors said.
No one at the Public Health Agency of Canada was available to comment on Monday. But health officials have told CBC News they are currently studying possibilities for rolling out the vaccine, and expect to release recommendations within weeks.
More information:
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- The H1N1 vaccine race: Can we beat the pandemic? Canadian Medical Association Journal
- http://www.cbc.ca/health/story/2009/08/31/h1n1-vaccine.html
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